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  • 产品名称：ShK

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  • 产品厂商：Smartox-Biotech
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简单介绍：
ShK
详情介绍：
Purpose ShK is a Kv1.3 channel selective blocker
Sequence Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OHDisulfid e bonds between Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
Background ShK has been isolated from the venom of the Carribean seaanemone Stoichactis helianthus. This toxin inhibits voltagedependentpotassium channels. It blocks Kv1.3 (KCNA3)potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6(KCNA6) respectively with 11 pM,16 pM and 165 pM.
Molecular Weight 4054.85 Da
Restrictions For Research Use only