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  • 产品名称：omega-conotoxinMVIIC(omegacontoxinMVIIC)

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  • 产品厂商：Smartox-Biotech
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简单介绍：
omega-conotoxinMVIIC(omegacontoxinMVIIC)
详情介绍：
Purpose omega-conotoxin MVIIC is a calcium channel blocker
Sequence Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys26
Background Omega-conotoxin MVIIC has been isolated from the venom of the cone Conus magus. omega-conotoxin MVIIC inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of omega-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. omega-conotoxin MVIIC also presents an inhibition of omega-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats.
Molecular Weight 2750.2 Da
CAS-No 147794-23-8
Restrictions For Research Use only