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  • 产品名称：omega-ConotoxinMVIIA(omegaconotoxinMVIIA)

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  • 产品厂商：Smartox-Biotech
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简单介绍：
omega-ConotoxinMVIIA(omegaconotoxinMVIIA)
详情介绍：
Purpose omega-Conotoxin MVIIA is a Cav2.2 channel blocker
Sequence Cys1-Lys-Gly-Lys-Gly-Ala-Lys-Cys8-Ser-Arg-Leu-Met-Tyr-Asp-Cys15-Cys16-Thr-Gly-Ser-Cys20-Arg-Ser-Gly-Lys-Cys25-NH2Disulfide bonds between Cys1-Cys16, Cys8-Cys20and Cys15-Cys25
Background Omega-Conotoxin MVIIA has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-sensitive calcium channels (VSCC). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B). Omega-conotoxin MVIIA is available under the name Prialt by Neurex. It blocks acute pain in patients who no longer obtain relief from opiate drugs. It is 100 to 1.000 times more potent than morphine. This toxin blocks calcium channels and disables nerves that transmit pain signals.
Molecular Weight 2639.18 Da
CAS-No 107452-89-1
Restrictions For Research Use only