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  • 产品名称：MT7-MuscarinicToxin7

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  • 产品厂商：Smartox-Biotech
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简单介绍：
MT7-MuscarinicToxin7
详情介绍：
Sequence AA sequence: Leu-Thr-Cys3-Val-Lys-Ser-Asn-Ser-Ile-Trp -Phe-Pro-Thr-Ser-Glu-Asp-Cys17-Pro-Asp-Gly -Gln-Asn-Leu-Cys24-Phe-Lys-Arg-Trp-Gln-Tyr -Ile-Ser-Pro-Arg-Met-Tyr-Asp-Phe-Thr-Arg -Gly-Cys42-Ala-Ala-Thr-Cys46-Pro-Lys-Ala-Glu-Tyr -Arg-Asp-Val-Ile-Asn-Cys57-Cys58-Gly- Thr-Asp-Lys-Cys63-Asn-Lys Disulfide bridges: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Characteristics Blocker of M1-subtype of muscarinic receptor
Background Muscarinic toxin 7 (MT7 - m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxin belongs to the three finger toxin family such as rho-Da1a.
Molecular Weight 7472.53 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Xu, Zhao, Zheng, Wang, Niu, Wang, Xu, Lu, Chen: "Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors." in: Journal of molecular recognition : JMR, Vol. 28, Issue 4, pp. 239-52, 2015 (PubMed).

Rondinelli, Näreoja, Näsman: "Molecular conversion of muscarinic acetylcholine receptor M(5) to muscarinic toxin 7 (MT7)-binding protein." in: Toxins, Vol. 3, Issue 11, pp. 1393-404, 2011 (PubMed).

Fruchart-Gaillard, Mourier, Marquer, Stura, Birdsall, Servent: "Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states." in: Molecular pharmacology, Vol. 74, Issue 6, pp. 1554-63, 2008 (PubMed).

Kukkonen, Peräkylä, Akerman, Näsman: "Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops." in: The Journal of biological chemistry, Vol. 279, Issue 49, pp. 50923-9, 2004 (PubMed).

Bradley, Rowan, Harvey: "Effects of muscarinic toxins MT2 and MT7, from green mamba venom, on m1, m3 and m5 muscarinic receptors expressed in Chinese Hamster Ovary cells." in: Toxicon : official journal of the International Society on Toxinology, Vol. 41, Issue 2, pp. 207-15, 2003 (PubMed).

Olianas, Maullu, Adem, Mulugeta, Karlsson, Onali: "Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7)." in: British journal of pharmacology, Vol. 131, Issue 3, pp. 447-52, 2000 (PubMed).