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  • 产品名称：Stromatoxin1(ScTx1)

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  • 产品厂商：Smartox-Biotech
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简单介绍：
Stromatoxin1(ScTx1)
详情介绍：
Sequence AA sequence: Asp-Cys2-Thr-Arg-Met-Phe-Gly-Ala-Cys9-Arg -Arg-Asp-Ser-Asp-Cys15-Cys16-Pro-His-Leu-Gly- Cys21-Lys-Pro-Thr-Ser-Lys-Tyr-Cys28-Ala-Trp- Asp-Gly-Thr-Ile-NH2 Disulfide bonds: Cys2-Cys16, Cys9-Cys21 and Cys15-Cys28
Characteristics Stromatoxin 1 (ScTx1) is a blocker of Kv2 channels
Background Stromatoxin-1 inhibits with high affinities Kv2.1 and Kv2.2, that encode delayed K+ channels (respectively, with IC50 of 12 and 21 nM). The block is voltage-dependent and slowly reversible. It is also a very sensitive inhibitor of Kv4.2, that encodes a transient K+ current (IC50 of 1.2 nM). Here also, the block is voltage-dependent indicating that ScTx-1 acts as a gating modifier rather than a pore blocker. Reversibility is faster on Kv4.2 channels. In contrast, ScTx-1 has no effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6 or Kv3.4 channels.
Molecular Weight 3791.3 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Shiau, Huang, Liou, Liaw, Shiau, Lou: "Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels." in: Chemical research in toxicology, Vol. 16, Issue 10, pp. 1217-25, 2003 (PubMed).