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  • 产品名称：α-conotoxinGID

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  • 产品厂商：Smartox-Biotech
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简单介绍：
α-conotoxinGID
详情介绍：
Sequence AA sequence: Ile-Arg-Asp-Gla-Cys5-Cys6-Ser-Asn-Pro-Ala- Cys11-Arg-Val-Asn-Asn-Hyp-His-Val-Cys19-OH Disulfide bonds: Cys5-Cys11 and Cys6-Cys19
Characteristics α-conotoxin GID is a blocker of α3β2, α7 and α4β2 nAChRsNicotinic acetylcholine receptor (nAChR) blocker
Background α-conotoxin GID is a peptide originally isolated from the venom of the Conus geographus. It is composed of 19 amino acids and is folded by two disulphide bonds connecting Cys1-Cys3 and Cys2-Cys4. Based on the number of amino acids between the second and the third cysteine residues (loop I) and the third and fourth cysteine residues (loop II), α-conotoxin GID belongs to the α4/7-conotoxin family. α-conotoxin GID blocks selectively neuronal nicotinic acetylcholine receptors with IC50 values of 3 nM (α3β2 nicotinic receptors), 5 nM (α7) and 150 nM (α4β2). α-conotoxin GID is at least 1000-fold less potent onto the α1β1γδ, α3β4, and α4β4 nicotinic receptors. α-conotoxin GID is a unique α4/7-conotoxin because of its ability to block both α7 and α3β2 isoforms, contrary to conotoxin PnIA or PnIB that are more selective.
Molecular Weight 2185.45 kDa
Restrictions For Research Use only
Storage -20 °C
Expiry Date 2 months
Background publications Banerjee, Yongye, Chang, Gyanda, Medina-Franco, Armishaw: "Design and synthesis of ?-conotoxin GID analogues as selective ?4?2 nicotinic acetylcholine receptor antagonists." in: Biopolymers, Vol. 102, Issue 1, pp. 78-87, 2014 (PubMed).

Millard, Nevin, Loughnan, Nicke, Clark, Alewood, Lewis, Adams, Craik, Daly: "Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues." in: The Journal of biological chemistry, Vol. 284, Issue 8, pp. 4944-51, 2009 (PubMed).