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  • 产品名称：Rho-conotoxinTIA

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  • 产品厂商：Smartox-Biotech
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简单介绍：
Rho-conotoxinTIA
详情介绍：
Sequence AA sequence: Phe-Asn-Trp-Arg-Cys5-Cys6-Leu-Ile-Pro-Ala -Cys11-Arg-Arg-Asn-His-Lys-Lys-Phe-Cys19-NH2 Disulfide bonds: Cys5-Cys11 and Cys6-Cys19
Characteristics Rho-conotoxin TIA is a selective blocker of α1-adrenoreceptors
Background Rho-conotoxin TIA has been isolated from the venom of the fish-hunting marine cone snail Conus tulipa. Rho-conotoxin TIA is a selective antagonist of α1-adrenoreceptor (α1A-, α1B- and α1D-AR). It acts non-competitively onto α1B-adrenoreceptor but competitively on α1A-adrenoreceptor and α1D-adrenoreceptor. The most important residue for activity is Arg4. Rho-conotoxin TIA is 10-fold selective for human α1B-adrenoreceptor over α1A-adrenoreceptor and α1D-adrenoreceptor. The IC50 values for Rho-conotoxin TIA for inhibition of 125I-BE were 18 nM for human α1A-AR, 2 nM for α1B-AR and 25 nM for α1D-AR.
Molecular Weight 2390.90 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Kamikihara, Mueller, Lima, Silva, da Costa, Buratini, Pupo: "Differential distribution of functional alph}1-adrenergic receptor subtypes along the rat tail artery." in: The Journal of pharmacology and experimental therapeutics, Vol. 314, Issue 2, pp. 753-61, 2005 (PubMed).

Chen, Rogge, Hague, Alewood, Colless, Lewis, Minneman: "Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35326-33, 2004 (PubMed).

Sharpe, Thomas, Loughnan, Motin, Palant, Croker, Alewood, Chen, Graham, Alewood, Adams, Lewis: "Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34451-7, 2003 (PubMed).