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  • 产品名称：rho-Da1b-AdTx1

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  • 产品厂商：Smartox-Biotech
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简单介绍：
rho-Da1b-AdTx1
详情介绍：
Sequence AA sequence: Leu-Thr-Cys3-Val-Thr-Ser-Lys-Ser-Ile-Phe- Gly-Ile-Thr-Thr-Glu-Asp-Cys17-Pro-Asp-Gly -Gln-Asn-Leu-Cys24-Phe-Lys-Arg-Arg-His-Tyr-Val -Val-Pro-Lys-Ile-Tyr-Asp-Ser-Thr-Arg -Gly-Cys42-Ala-Ala-Thr-Cys46-Pro-Ile-Pro-Glu -Asn-Tyr-Asp-Ser-Ile-His-Cys57-Cys58-Lys-Thr -Asp-Lys-Cys63-Asn-Glu Disulfide bridges: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Characteristics Selective antagonist of the alpha(1A)-adrenoceptor
Background AdTx1 (rho-Da1a - ?-Da1b) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles
Molecular Weight 7283.29 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications Blanchet, Collet, Mourier, Gilles, Fruchart-Gaillard, Marcon, Servent: "Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins." in: Biochimie, Vol. 103, pp. 109-17, 2014 (PubMed).

Maïga, Vera, Marchetti, Lorphelin, Bellanger, Mourier, Servent, Gilles, Stura: "Crystallization of recombinant green mamba ?-Da1a toxin during a lyophilization procedure and its structure determination." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 69, Issue Pt 6, pp. 704-9, 2013 (PubMed).

Palea, Maiga, Guilloteau, Rekik, Guérard, Rouget, Rischmann, Botto, Camparo, Lluel, Gilles: "Effects of ?-Da1a a peptidic ?(1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats." in: British journal of pharmacology, Vol. 168, Issue 3, pp. 618-31, 2013 (PubMed).

Maïga, Merlin, Marcon, Rouget, Larregola, Gilquin, Fruchart-Gaillard, Lajeunesse, Marchetti, Lorphelin, Bellanger, Summers, Hutchinson, Evans, Servent, Gilles: "Orthosteric binding of ?-Da1a, a natural peptide of snake venom interacting selectively with the ?1A-adrenoceptor." in: PLoS ONE, Vol. 8, Issue 7, pp. e68841, 2013 (PubMed).

Maïga, Mourier, Quinton, Rouget, Gales, Denis, Lluel, Sénard, Palea, Servent, Gilles: "G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors." in: Toxicon : official journal of the International Society on Toxinology, Vol. 59, Issue 4, pp. 487-96, 2012 (PubMed).

Quinton, Girard, Maiga, Rekik, Lluel, Masuyer, Larregola, Marquer, Ciolek, Magnin, Wagner, Molgó, Thai, Fruchart-Gaillard, Mourier, Chamot-Rooke, Ménez, Palea, Servent, Gilles: "Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor." in: British journal of pharmacology, Vol. 159, Issue 2, pp. 316-25, 2010 (PubMed).