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  • 产品名称：α-conotoxinPeIA

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  • 产品厂商：Smartox-Biotech
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简单介绍：
α-conotoxinPeIA
详情介绍：
Sequence AA sequence: Gly-Cys2-Cys3-Ser-His-Pro-Ala-Cys8-Ser-Val -Asn-His-Pro-Glu-Leu-Cys16-NH2 Disulfide bonds: Cys2-Cys8, Cys3-Cys16
Characteristics α-conotoxin PeIA discriminates between α9α10 and α7 nAChRs
Background α-conotoxin PeIA has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 μM, respectively ). α-conotoxin PeIA is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 μM α-conotoxin PeIA. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
Molecular Weight 1651.9 kDa
Restrictions For Research Use only
Storage -20 °C
Background publications McIntosh, Plazas, Watkins, Gomez-Casati, Olivera, Elgoyhen: "A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors." in: The Journal of biological chemistry, Vol. 280, Issue 34, pp. 30107-12, 2005 (PubMed).