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  • 产品名称：Phrixotoxin-2

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  • 产品厂商：Smartox-Biotech
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简单介绍：
Phrixotoxin-2
详情介绍：
Sequence AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp -Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val -Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2 Disulfide bonds:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
Characteristics Phrixotoxin-2 is a selective blocker of Kv4.2 and Kv4.3 channels
Background Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin.
Molecular Weight 3921.71 kDa
CAS-No 221889-63-0
Restrictions For Research Use only
Storage -20 °C
Background publications Diochot, Drici, Moinier, Fink, Lazdunski: "Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis." in: British journal of pharmacology, Vol. 126, Issue 1, pp. 251-63, 1999 (PubMed).