Immunogen
|
Prelamin A C-terminus peptide
|
Specificity
|
Anti prelamin A polyclonal antibody detects fulllength prelamin A which has not yet undergone to proteolytic steps, both in its nonfarnesylated and in its farnesylated form. The farnesylated form of fulllength prelamin A is labelled by antibody with lower efficiency. The antibody does not cross react with mature lamin A.
|
Characteristics
|
Several laminopathies are characterized by anomalous accumulation of prelamin A. This polyclonal antibody is able to detect full-lenght prelamin A, while it does not recognize either mature lamin A or cleaved prelamin A intermediates.
|
Purification
|
Polyclonal immunoglobulins purified by protein A affinity chromatography and stabilized with 5% of glycerol.
|