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  • 产品名称:anti-Sirtuin5(SIRT5)(AA263-292)antibody

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  • 产品厂商:NSJBio
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简单介绍:
anti-Sirtuin5(SIRT5)(AA263-292)antibody
详情介绍:
Immunogen A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.
Isotype Ig Fraction
Purification Purified
Alternative Name SIRT5 (SIRT5 Antibody Abstract)
Background SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]
UniProt Q9NXA8
Research Area Chromatin and Nuclear Signaling, Proteases
Application Notes Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
Restrictions For Research Use only
Format Liquid
Buffer In 1X PBS,?pH 7.4, with 0.09?% sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aliquot the SIRT5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-Sirtuin 5 (SIRT5) (AA 263-292) antibody (ABIN3032595) IHC analysis of FFPE human hepatocarcinoma tissue stained with the SIRT5 antibody
Western Blotting (WB) image for anti-Sirtuin 5 (SIRT5) (AA 263-292) antibody (ABIN3032595) Western blot analysis of SIRT5 antibody in Jurkat lysate