Alternative Name
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ADAM17 (ADAM17 Antibody Abstract)
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Background
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ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway.
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UniProt
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P78536
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Research Area
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Cancer, Proteolysis / Ubiquitin, Metalloprotease, Alzheimer's Disease
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Pathways
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Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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