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  • 产品名称:anti-ADAM17antibody(ADAMMetallopeptidaseDomain17)(AA195-224)

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  • 产品厂商:NSJBio
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简单介绍:
anti-ADAM17antibody(ADAMMetallopeptidaseDomain17)(AA195-224)
详情介绍:
Immunogen A portion of amino acids 195-224 from the human protein was used as the immunogen for this ADAM17 antibody.
Isotype Ig Fraction
Purification Antigen affinity purified
Alternative Name ADAM17 (ADAM17 Antibody Abstract)
Background ADAM17 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. ADAM17 functions as a tumor necrosis factor-alpha converting enzyme, binds mitotic arrest deficient 2 protein, and also plays a prominent role in the activation of the Notch signaling pathway.
UniProt P78536
Research Area Cancer, Proteolysis / Ubiquitin, Metalloprotease, Alzheimer's Disease
Pathways Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Application Notes Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50
Restrictions For Research Use only
Format Liquid
Buffer In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Aliquot the ADAM17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Supplier Images
Flow Cytometry (FACS) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 195-224) antibody (ABIN3029858) Flow cytometric analysis of CEM cells using ADAM17 antibody (green) compared to a neg...
Western Blotting (WB) image for anti-ADAM Metallopeptidase Domain 17 (ADAM17) (AA 195-224) antibody (ABIN3029858) Western blot analysis of ADAM17 antibody and CEM lysate